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Healthcode's self-developed D2P cell-free protein synthesis technology needs only water and DNA to express protein. Expression is simple and efficient and industrialization-friendly, with a short single-reaction time that is particularly suited to wet-lab validation for AI4S. Centered on this core technology, Healthcode has launched the Nuoto® fully automated nucleic acid extractor: high throughput, faster and less laborious, it meets various downstream experimental needs including cell-free protein expression. The product is now widely used in nearly a thousand university and institute laboratories as well as institutions and companies across the country, and is well recognized by teachers, students and researchers.
To meet researchers' demand for high-throughput, high-quality, automated, fast and convenient nucleic acid extraction, the Nuoto® fully automated nucleic acid extraction system was created. The system consists of the Nuoto® fully automated nucleic acid extractor and more than 8 types of 5fz series nucleic acid extraction kits. Device and kits work as an integrated whole, automatically completing the full process of target nucleic acid release, binding, washing and elution without manual intervention.
The Nuoto® fully automated nucleic acid extractor is available in 8/16/32-channel formats and can extract 32 sets of target nucleic acid in a single run. Equipped with 32 strong magnetic rods, Nuoto® rapidly and automatically completes DNA/RNA extraction of 1–32 samples. Its highly stable automated control system effectively avoids human operational deviation, so results are stable and reproducible. Nuoto® covers eight functions — plasmid extraction, genomic extraction, cellular RNA extraction, PCR cleanup, gel recovery, nucleic acid concentration and endotoxin removal — meeting the needs of the vast majority of molecular biology experiments, with faster turnaround, better repeatability and more convenient operation.
To cover different nucleic acid extraction needs, the Nuoto® fully automated nucleic acid extractor is paired with 5fz series magnetic bead nucleic acid extraction kits. Micron magnetic beads automatically perform nucleic acid binding, washing and elution, extracting 16 samples (one box) or 32 samples (two boxes) in one batch — high throughput, high concentration, high purity, less manual work and lower cost:
Whether plasmid (mini, midi, maxi) extraction, genomic DNA extraction, cellular RNA extraction, PCR purification, gel recovery, nucleic acid concentration or endotoxin removal — the 5fz series kits cover them in one stop. The resulting nucleic acid has high yield and good purity and can be used directly in downstream experiments such as PCR, in vitro transcription, sequencing, restriction digestion, transformation, NGS, DNA cloning and Southern blotting.
Every detail of Nuoto® exists to improve extraction efficiency and experimental reliability:
1Fully automated one-button start. No manual intervention and no centrifugation; the entire extraction runs automatically, completely freeing up manpower.
2High throughput, faster and less laborious. 32 strong magnetic rods work in parallel to complete DNA/RNA extraction of 1–32 samples in a short time.
3Better repeatability. The highly stable automated control system effectively avoids human operational deviation, for stable and reliable results.
4Meets the vast majority of extraction needs: plasmid (mini, midi & maxi) extraction, genomic DNA extraction, cellular RNA extraction, PCR purification, gel recovery, nucleic acid concentration and endotoxin removal.
5Efficient contamination control. Timer-controlled UV sterilization significantly reduces laboratory contamination rates.
6Fully automated and safer. The program pauses automatically when the door opens; a built-in exhaust system with timed UV sterilization, plus disposable consumables, reduces operator contact with hazardous reagents.
7More convenient. A 10-inch color touch screen with Chinese and English display and touch operation; 100% domestically produced.
8Smarter and more worry-free. Intelligent calibration, automatic online upgrades and remote maintenance; modular structure with upgraded core components for higher precision, lower failure rates and easier maintenance.
9Worry-free after-sales. Response within 24 hours; hardware failure replaced with a new machine within five years.
One Nuoto® replaces a mixer, a centrifuge, a balance, a pH meter and pipettes — along with large numbers of centrifuge tubes, tips and endless manual labor — upgrading nucleic acid extraction from tedious handwork to a fully automated, high-throughput, high-quality standardized workflow.
The Nuoto® fully automated nucleic acid extraction system suits plasmid extraction from the vast majority of E. coli strains, as well as genomic DNA and cellular RNA extraction from plants, animals, tumors, fungi, bacteria, mycoplasma, chlamydia, viruses and many other sources. RNA structure stays intact, cell types are universal, sample types are universal, no cell-wall lysis pretreatment is required and the process is fully automatic. The system is restricted to research use by scientific research institutions and provides a stable, efficient and integrated automated solution for high-throughput nucleic acid extraction experiments.
If nucleic acid extraction still keeps you trapped in centrifugation, lysis and repeated manual steps, the Nuoto® fully automated nucleic acid extraction system is the answer you have been waiting for. With 32-channel parallelism and applicability to every kind of nucleic acid extraction, it redefines the standard for high-throughput extraction; with eight functions and the 5fz series kits, it covers the vast majority of molecular biology experiments in one stop; and with a fully automated, safer and less laborious experience, it gives researchers' precious time back to genuine scientific discovery. Choose Nuoto® — and make every DNA/RNA extraction faster, purer and easier.
Cell-free protein is the inevitable path of the AI bio era! The world's No.1 fully automated cell-free synthesis intelligent system is in China: Healthcode Protein Factory, Nuoto, Pruoto, AMPitor, Reactor and D2Pi-AutoLab. With advanced underlying technologies as the cornerstone, we fully support the disruptive development of biomanufacturing and the biopharmaceutical industry, helping research institutions and enterprises build a double-helix development model of "innovation capability and R&D pipeline" and enhance their core competitiveness.
