Uniform Biological Material Transfer Agreement – MTA

Definitions

1. PROVIDER: Organization providing the ORIGINAL MATERIAL. The name and address of this party will be specified in an implementing letter.
2. PROVIDER SCIENTIST: The name and address of this party will be specified in an implementing letter.
3. RECIPIENT: Organization receiving the ORIGINAL MATERIAL. The name and address of this party will be specified in an implementing letter.
4. RECIPIENT SCIENTIST: The name and address of this party will be specified in an implementing letter.
5. ORIGINAL MATERIAL: The description of the material being transferred will be specified in an implementing letter.
6. MATERIAL: ORIGINAL MATERIAL, and PROGENY. The MATERIAL shall not include: (a) MODIFICATIONS, or (b) other substances created by the RECIPIENT through the use of the MATERIAL which are not MODIFICATIONS, PROGENY, or UNMODIFIED DERIVATIVES.
7. PROGENY: Unmodified descendant from the MATERIAL, such as virus from virus, cell from cell, or organism from organism, DNA/RNA duplicated by DNA/RNA supplied by the PROVIDER, purified or fractionated subsets of the ORIGINAL MATERIAL.
8. UNMODIFIED DERIVATIVES: Substances created by the RECIPIENT which constitute an unmodified functional subunit or product expressed by the ORIGINAL MATERIAL. Some examples include: proteins expressed by DNA/RNA supplied by the PROVIDER, or monoclonal antibodies secreted by a hybridoma cell line.
9. MODIFICATIONS: Substances created by the RECIPIENT which contain/incorporate the MATERIAL, and UNMODIFIED DERIVATIVES.
10. COMMERCIAL PURPOSES: The sale, lease, license, or other transfer of the MATERIAL or MODIFICATIONS to a for-profit organization. COMMERCIAL PURPOSES shall also include uses of the MATERIAL or MODIFICATIONS by any organization, including RECIPIENT, to perform contract research, to screen compound libraries, to produce or manufacture products for general sale, or to conduct research activities that result in any sale, lease, license, or transfer of the MATERIAL or MODIFICATIONS to a for-profit organization. However, industrially sponsored academic research shall not be considered a use of the MATERIAL or MODIFICATIONS for COMMERCIAL PURPOSES per se, unless any of the above conditions of this definition are met.
11. NONPROFIT ORGANIZATION(S): A university or other institution of higher education or an organization any nonprofit scientific or educational organization qualified under a nonprofit organization statute. As used herein, the term also includes government agencies.

Terms and Conditions of this Agreement

1. The PROVIDER retains ownership of the MATERIAL, including any MATERIAL contained or incorporated in MODIFICATIONS.

2. The RECIPIENT retains ownership of: (a) MODIFICATIONS (except that, the PROVIDER retains ownership rights to the MATERIAL included therein), and (b) those substances created through the use of the MATERIAL or MODIFICATIONS, but which are not PROGENY, UNMODIFIED DERIVATIVES or MODIFICATIONS (i.e., do not contain the ORIGINAL MATERIAL, PROGENY, UNMODIFIED DERIVATIVES). If either 2 (a) or 2 (b) results from the collaborative efforts of the PROVIDER and the RECIPIENT, joint ownership may be negotiated.

a) is to be used solely for teaching and academic research purposes;
b) will not be used in human subjects, in clinical trials, or for diagnostic purposes involving human subjects without the written consent of the PROVIDER;
c) is to be used only at the RECIPIENT organization and only in the RECIPIENT SCIENTIST's laboratory under the direction of the RECIPIENT SCIENTIST or others working under his/her direct supervision;
d) will not be transferred to anyone else outside the RECIPIENT organization without the prior written consent of the PROVIDER.

4. The RECIPIENT and the RECIPIENT SCIENTIST agree to refer to the PROVIDER any request for the MATERIAL from anyone other than those persons working under the RECIPIENT SCIENTIST's direct supervision. To the extent supplies are available, the PROVIDER or the PROVIDER SCIENTIST agrees to make the MATERIAL available, under a separate implementing letter to this Agreement or other agreement having terms consistent with the terms of this Agreement, to other scientists (at least those at NONPROFIT ORGANIZATION(S)) who wish to replicate the RECIPIENT SCIENTIST's research; provided that such other scientists reimburse the PROVIDER for any costs relating to the preparation and distribution of the MATERIAL.

a) The PROVIDER and/or the PROVIDER SCIENTIST shall have the right, without restriction, to distribute substances created by the PROVIDER through the use of the ORIGINAL MATERIAL only if those substances are not PROGENY, UNMODIFIED DERIVATIVES, or MODIFICATIONS.
b) Under a separate implementing letter to this Agreement (or an agreement at least as protective of the PROVIDER's rights), the RECIPIENT and/or the RECIPIENT SCIENTIST may distribute substances created by the RECIPIENT through the use of the ORIGINAL MATERIAL only if those substances are not PROGENY, UNMODIFIED DERIVATIVES, or MODIFICATIONS.
c) The PROVIDER and/or the PROVIDER SCIENTIST shall have the right, without restriction, to distribute MODIFICATIONS to NONPROFIT ORGANIZATION(S) for research and teaching purposes only.
d) The PROVIDER and/or the PROVIDER SCIENTIST shall have the right, without restriction, to distribute MATERIAL for COMMERCIAL PURPOSES. It is recognized by the PROVIDER that such COMMERCIAL PURPOSES may NOT require a commercial license from the RECIPIENT and the RECIPIENT has no obligation to grant a commercial license to its ownership interest in the MATERIAL. Nothing in this paragraph, however, shall prevent the PROVIDER from granting commercial licenses under the PROVIDER's intellectual property rights claiming such MATERIAL, or methods of their manufacture or their use.
e) The RECIPIENT and/or the RECIPIENT SCIENTIST shall have the right, without restriction, to distribute MODIFICATIONS for COMMERCIAL PURPOSES. It is recognized by the RECIPIENT that such COMMERCIAL PURPOSES may NOT require a commercial license from the PROVIDER and the PROVIDER has no obligation to grant a commercial license to its ownership interest in the MATERIAL incorporated in the MODIFICATIONS. Nothing in this paragraph, however, shall prevent the RECIPIENT from granting commercial licenses under the RECIPIENT's intellectual property rights claiming such MODIFICATIONS, or methods of their manufacture or their use.

6. The RECIPIENT acknowledges that the MATERIAL is or may be the subject of a patent application. Except as provided in this Agreement, no express or implied licenses or other rights are provided to the RECIPIENT under any patents, patent applications, trade secrets or other proprietary rights of the PROVIDER, including any altered forms of the MATERIAL made by the PROVIDER. In particular, no express or implied licenses or other rights are provided to use the MATERIAL, MODIFICATIONS, or any related patents of the PROVIDER for COMMERCIAL PURPOSES.

7. If the RECIPIENT desires to use or license the MATERIAL for COMMERCIAL PURPOSES, the RECIPIENT agrees, in advance of such use, to negotiate in good faith with the PROVIDER to establish the terms of a commercial license. It is understood by the RECIPIENT that the PROVIDER shall have no obligation to grant such a license to the RECIPIENT, and may grant exclusive or non-exclusive commercial licenses to others, or sell or assign all or part of the rights in the MATERIAL to any third party(ies), subject to any pre-existing rights held by others and obligations to the Federal Government.

8. If the PROVIDER desires to use or license the MODIFICATIONS for COMMERCIAL PURPOSES, the PROVIDER agrees, in advance of such use, to negotiate in good faith with the RECIPIENT to establish the terms of a commercial license. It is understood by the PROVIDER that the RECIPIENT shall have no obligation to grant such a license to the PROVIDER, and may grant exclusive or non-exclusive commercial licenses to others, or sell or assign all or part of the rights in the MODIFICATIONS to any third party(ies), subject to any pre-existing rights held by others and obligations to theGovernment.

9. The PROVIDER is free to file patent application(s) claiming inventions made by the PROVIDER through the use of the MODIFICATIONS but agrees to notify the RECIPIENT upon filing a patent application claiming MATERIAL or method(s) of manufacture or use(s) of the MATERIAL.

10. The RECIPIENT is free to file patent application(s) claiming inventions made by the RECIPIENT through the use of the MATERIAL but agrees to notify the PROVIDER upon filing a patent application claiming MODIFICATIONS or method(s) of manufacture or use(s) of the MATERIAL.

11. Any MATERIAL delivered pursuant to this Agreement is understood to be experimental in nature and may have hazardous properties. The PROVIDER MAKES NO REPRESENTATIONS AND EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESSED OR IMPLIED. THERE ARE NO EXPRESS OR IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR THAT THE USE OF THE MATERIAL WILL NOT INFRINGE ANY PATENT, COPYRIGHT, TRADEMARK, OR OTHER PROPRIETARY RIGHTS.

12. Except to the extent prohibited by law, the RECIPIENT assumes all liability for damages which may arise from its use, storage or disposal of the MATERIAL. The PROVIDER will not be liable to the RECIPIENT for any loss, claim or demand made by the RECIPIENT, or made against the RECIPIENT by any other party, due to or arising from the use of the MATERIAL by the RECIPIENT, except to the extent permitted by law when caused by the gross negligence or willful misconduct of the PROVIDER.

13. This agreement shall not be interpreted to prevent or delay publication of research findings resulting from the use of the MATERIAL or the MODIFICATIONS. The PROVIDER SCIENTIST agrees to provide appropriate acknowledgment of the source of the MODIFICATIONS in all publications. The RECIPIENT SCIENTIST agrees to provide appropriate acknowledgment of the source of the MATERIAL in all publications.

14. The PROVIDER agrees to use the MODIFICATIONS in compliance with all applicable statutes and regulations, including Public Health Service and National Institutes of Health regulations and guidelines such as, for example, those relating to research involving the use of animals or recombinant DNA. The RECIPIENT agrees to use the MATERIAL in compliance with all applicable statutes and regulations, including Public Health Service and National Institutes of Health regulations and guidelines such as, for example, those relating to research involving the use of animals or recombinant DNA.

i) if termination should occur under 15(a), the RECIPIENT shall be bound to the PROVIDER by the least restrictive terms applicable to the MATERIAL obtained from the then-available resources; and
ii) if termination should occur under 15(b) or (d) above, the RECIPIENT will discontinue its use of the MATERIAL and will, upon direction of the PROVIDER, return or destroy any remaining MATERIAL. The RECIPIENT, at its discretion, will also either destroy the MODIFICATIONS or remain bound by the terms of this agreement as they apply to MODIFICATIONS; and
iii) In the event the PROVIDER terminates this Agreement under 15( c) other than for breach of this Agreement or for cause such as an imminent health risk or patent infringement, the PROVIDER will defer the effective date of termination for a period of up to one year, upon request from the RECIPIENT, to permit completion of research in progress. Upon the effective date of termination, or if requested, the deferred effective date of termination, RECIPIENT will discontinue its use of the MATERIAL and will, upon direction of the PROVIDER, return or destroy any remaining MATERIAL. The RECIPIENT, at its discretion, will also either destroy the MODIFICATIONS or remain bound by the terms of this agreement as they apply to MODIFICATIONS.

16.Paragraphs 6, 11 and 12 shall survive termination.

17.The MATERIAL is provided at no cost, or with an optional transmittal fee solely to reimburse the PROVIDER for its preparation and distribution costs. If a fee is requested by the PROVIDER, the amount will be indicated in an implementing letter. Main Text Ends Here.

RECIPIENT: Kangma-Healthcode (Shanghai) Biotech Co. Ltd.
RECIPIENT SCIENTIST: Rongrong Zhan
RECIPIENT ADDRESS: Building 15, Lane 118 Furonghua Road, Shanghai 201321, CHINA
RECIPIENT TEL: 021-58086922
RECIPIENT EMAIL: customer@healthcodon.com

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Protedino Protein Factory

Protedino 蛋白质工厂（生物医药专用）

产品编号

KMbtLyec10

合作申请

规格

1.25kg

我们所有的产品都有30天的退货/退款政策保证。请百分百放心地购物。

订单总额超200元包邮

Request Coorperation/Price

Product Description

蛋白质工厂

Protein Factory 1.0

更简单省时

Simpler and

time-saving
更高得率

High rate

更有活性

More active
高通量兼容性

High throughput

compatibility

世界最高效之蛋白质合成系统

World Most Efficient Protein Synthesis System

Protein

Factory

VER 1.0

蛋白质工厂是一种复制-转录-翻译偶联的体外蛋白质合成体系，包含DNA扩增、 mRNA转录和蛋白质翻译必需的全部组分。

Protein Factory is an in vitro protein synthesis system with coupled duplication-transcription-translation reactions, containing all necessary components of DNA duplication, mRNA transcription and protein translation.

全新D2P专利技术

仅需要加入水和DNA

Only need to add H2O and DNA

用全新的D2P科技，蛋白质工厂能够快速、简便、高通量地生产mg级的，生物活性的蛋白质。

Powered by patented D2P technology, first in history, ProteinFactory can rapidly, simply and in a high-throughput way to generate miligrams of biofunctional proteins.

解决复杂的蛋白质合成难题

Resolve Challenges of Protein Systhesis

产品基于真核细胞，对于合成糖基化/去糖基化、抗体和细胞因子等复杂蛋白更有优势。

The products are based on eukaryotic cells and have advantages in challenging proteins such as glycosylation/deglycosylation, antibodies, cytokines, etc.

更快速

SUPER FAST

2-3 Hours

Room Temperture

蛋白质工厂包含mRNA转录和蛋白质合成必需的所有组分，只需将DNA模板、反应缓冲液和真核细胞提取物混合，置于室温（20 - 30℃）条件下1-2小时，就能得到目标蛋白，不需要复杂操作和其他设备的辅助，为使用者节省大量时间和精力。

Protein Factory encompasses the full elements for mRNA transcription and protein translation. Just add DNA template, buffer to the product powder, at room temperature (20 - 30℃) , 1 to 2 hours, the target protein will be made. No complicated operations or auxiliary equipment required, save your time and energy.

更具放大性

SUPER SCALE

室温条件下，可一步实现从DNA模板到蛋白质的全部过程，不需其他设备，可缩小反应体积至1μL, 更可放大反应规模至 1 吨。

Protein is now made in one step from DNA template, at room temperature, without any equipment, easily enlargeable reaction scales from μL to tons.

更有活性

More active

蛋白质工厂试剂盒基于真核细胞，表达的具有生物学活性的蛋白质种类更多，对于合成糖基化/去糖基化蛋白质、抗体、细胞因子、膜蛋白和大分子蛋白质复合物等复杂蛋白更具优势。

ProteinFactory is based on eukaryotic cells, can express biologically active and well-folded proteins with more advantages, including glycosylated/deglycosylated proteins, antibodies, cytokines, membrane proteins, protein complexes and other complicated proteins.

D2P Tech

更高得率

High yield

蛋白质工厂能够生产毫克-克-公斤级重组蛋白。以萤火虫荧光素酶 (Firefly luciferase, Fluc) 为例，在0.3 μL反应体系中合成的荧光素酶发出荧光的相对光单位值 (Relative light unit, RLU) 达到了1 × 10e9，对应的蛋白质产量达到了200 μg/mL。

ProteinFactory can produce milligram-gram-kilograms of target recombinant proteins. Using Fluorescent luciferase (Fluc) as example, the relative light unit (RLU) of luciferase synthesized in a 0.3 μL reaction system reaches 1 × 10⁹, with a corresponding protein yield of 0.2-2 mg/10 mL.

更高通量

High Throughput

蛋白质工厂能够对多种目标蛋白 1-10000种同时进行表达，可快速筛选不同的突变体，可以按照最优的表达条件或者表现最好的目标蛋白进行生产规模的扩大，可以高通量检测目标蛋白的活性，更可用于进行直接的定向优化改造等。

ProteinFactory can express 1-10000 proteins simultaneously, screen mutations, optimize expression conditions or select optimal sequence for large-scale production, can perform high throughput functional assays, and can even be used for direct evolution of your favorite protein.

应用

APPLICATIONS

1. FPLC
2. NMR
1. Protein Complex
2. Medicine

1. ASSAY
2. Antibody
1. Membrane Protein
2. Cryo-EM

标准化的载体

Standardized Vector

pD2p pD2p_His8
pD2p_V5 pD2p_His8_Flus
pD2p_GST pD2p_His8_eGFP
pD2p_Flag pD2p_eGFP_Flag
pD2p_Fluc pD2p_Histev_eGFP
pD2p_MBP pD2p_Flag_eGFP
pD2p_eGFP_V5 pD2p_MBPtev_eGFP

世界上第一个DNA-to-Protein (D2P) 技术

World First DNA-to-Protein (D2P) Technology

Transcription
Translation
Protein

超过26项专利赋予的D2P技术，把整个中心法则囊括于内，是世界上唯一的直接从ng级DNA合成mg级蛋白质的技术。

With over 26 patents, the full Central Dogma recapitulated inside, ProteinFactory is world only technology to amplify ng DNA into mg Protein.

蛋白质工厂新成员

New members of Protein Factory

应用于药品生产材料供应领域，研发出具有合成药用活性蛋白的商业化产品

Applied in the field of pharmaceutical production material supply. Develop commercial products with synthetic pharmaceutical active proteins.

产品介绍

Introduction

本产品由活性酵母制成，采用先进的生物工艺从酵母细胞中提取蛋白质、多肽和核酸。提取物还含有多种维生素和微量元素。本产品生产工艺严格，可用于生物医用材料。160吨蛋白质生产线生产，技术成熟，质量稳定，满足客户的高品质要求。

This product is made from active yeast and uses advanced biological processes to extract proteins, peptides, nucleic acids from yeast cells. The extract also contains various vitamins and trace elements. The production process of this product is much stricter and can be used for biomedical materials. It is produced by a 160 ton protein factory line with mature technology and stable quality to meet customers' high-quality requirements.

品质稳定

Quality Stability

160吨蛋白质工厂生产线、工艺成熟、产品管线丰富。生产流程标准化，品质稳定。

160 tons protein factory production line, mature process, and rich product pipelines. Standardization of production process and stable quality.

包装描述

Kit Description

Protedino 蛋白质工厂（生物医药专用）

Protein Factory 1.0

产品信息

Product Information

产品名称：Protedino 蛋白质工厂（生物医药专用）

Product Name: Protedino Protein Factory
性状：粉状

Character: Powdery
净含量：1.25 kg

Net Weight: 1.25 kg
用途：药品生产材料

Usage: Pharmaceutical production materials
贮存条件：低温（0℃-25℃）、干燥处，密封保存

Storage conditions: Low temperature (0℃-25℃), dry place, sealed for storage.
保质期：1年

Shelf life: 1 year
注意事项：使用过后，请及时密封保存。

Attention: After use, please seal and store in a timely manner.

质量的全部保证

Quality Assurance

Protein Factory

BP Brand Promise We promise you are 100% satisfied with our products and shopping experience. If not, you may unconditional return any product you purchased from us.

No No toxic addition All products sold use environmental friendly materials with no toxic additives.
S After-sale warrant The most worry-free after-sales system

Re 30 days no reason to return In order to protect our consumers, you are free to return any
product within 30 days of purchase.