Uniform Biological Material Transfer Agreement – MTA

Definitions

1. PROVIDER: Organization providing the ORIGINAL MATERIAL. The name and address of this party will be specified in an implementing letter.
2. PROVIDER SCIENTIST: The name and address of this party will be specified in an implementing letter.
3. RECIPIENT: Organization receiving the ORIGINAL MATERIAL. The name and address of this party will be specified in an implementing letter.
4. RECIPIENT SCIENTIST: The name and address of this party will be specified in an implementing letter.
5. ORIGINAL MATERIAL: The description of the material being transferred will be specified in an implementing letter.
6. MATERIAL: ORIGINAL MATERIAL, and PROGENY. The MATERIAL shall not include: (a) MODIFICATIONS, or (b) other substances created by the RECIPIENT through the use of the MATERIAL which are not MODIFICATIONS, PROGENY, or UNMODIFIED DERIVATIVES.
7. PROGENY: Unmodified descendant from the MATERIAL, such as virus from virus, cell from cell, or organism from organism, DNA/RNA duplicated by DNA/RNA supplied by the PROVIDER, purified or fractionated subsets of the ORIGINAL MATERIAL.
8. UNMODIFIED DERIVATIVES: Substances created by the RECIPIENT which constitute an unmodified functional subunit or product expressed by the ORIGINAL MATERIAL. Some examples include: proteins expressed by DNA/RNA supplied by the PROVIDER, or monoclonal antibodies secreted by a hybridoma cell line.
9. MODIFICATIONS: Substances created by the RECIPIENT which contain/incorporate the MATERIAL, and UNMODIFIED DERIVATIVES.
10. COMMERCIAL PURPOSES: The sale, lease, license, or other transfer of the MATERIAL or MODIFICATIONS to a for-profit organization. COMMERCIAL PURPOSES shall also include uses of the MATERIAL or MODIFICATIONS by any organization, including RECIPIENT, to perform contract research, to screen compound libraries, to produce or manufacture products for general sale, or to conduct research activities that result in any sale, lease, license, or transfer of the MATERIAL or MODIFICATIONS to a for-profit organization. However, industrially sponsored academic research shall not be considered a use of the MATERIAL or MODIFICATIONS for COMMERCIAL PURPOSES per se, unless any of the above conditions of this definition are met.
11. NONPROFIT ORGANIZATION(S): A university or other institution of higher education or an organization any nonprofit scientific or educational organization qualified under a nonprofit organization statute. As used herein, the term also includes government agencies.

Terms and Conditions of this Agreement

1. The PROVIDER retains ownership of the MATERIAL, including any MATERIAL contained or incorporated in MODIFICATIONS.

2. The RECIPIENT retains ownership of: (a) MODIFICATIONS (except that, the PROVIDER retains ownership rights to the MATERIAL included therein), and (b) those substances created through the use of the MATERIAL or MODIFICATIONS, but which are not PROGENY, UNMODIFIED DERIVATIVES or MODIFICATIONS (i.e., do not contain the ORIGINAL MATERIAL, PROGENY, UNMODIFIED DERIVATIVES). If either 2 (a) or 2 (b) results from the collaborative efforts of the PROVIDER and the RECIPIENT, joint ownership may be negotiated.

a) is to be used solely for teaching and academic research purposes;
b) will not be used in human subjects, in clinical trials, or for diagnostic purposes involving human subjects without the written consent of the PROVIDER;
c) is to be used only at the RECIPIENT organization and only in the RECIPIENT SCIENTIST's laboratory under the direction of the RECIPIENT SCIENTIST or others working under his/her direct supervision;
d) will not be transferred to anyone else outside the RECIPIENT organization without the prior written consent of the PROVIDER.

4. The RECIPIENT and the RECIPIENT SCIENTIST agree to refer to the PROVIDER any request for the MATERIAL from anyone other than those persons working under the RECIPIENT SCIENTIST's direct supervision. To the extent supplies are available, the PROVIDER or the PROVIDER SCIENTIST agrees to make the MATERIAL available, under a separate implementing letter to this Agreement or other agreement having terms consistent with the terms of this Agreement, to other scientists (at least those at NONPROFIT ORGANIZATION(S)) who wish to replicate the RECIPIENT SCIENTIST's research; provided that such other scientists reimburse the PROVIDER for any costs relating to the preparation and distribution of the MATERIAL.

a) The PROVIDER and/or the PROVIDER SCIENTIST shall have the right, without restriction, to distribute substances created by the PROVIDER through the use of the ORIGINAL MATERIAL only if those substances are not PROGENY, UNMODIFIED DERIVATIVES, or MODIFICATIONS.
b) Under a separate implementing letter to this Agreement (or an agreement at least as protective of the PROVIDER's rights), the RECIPIENT and/or the RECIPIENT SCIENTIST may distribute substances created by the RECIPIENT through the use of the ORIGINAL MATERIAL only if those substances are not PROGENY, UNMODIFIED DERIVATIVES, or MODIFICATIONS.
c) The PROVIDER and/or the PROVIDER SCIENTIST shall have the right, without restriction, to distribute MODIFICATIONS to NONPROFIT ORGANIZATION(S) for research and teaching purposes only.
d) The PROVIDER and/or the PROVIDER SCIENTIST shall have the right, without restriction, to distribute MATERIAL for COMMERCIAL PURPOSES. It is recognized by the PROVIDER that such COMMERCIAL PURPOSES may NOT require a commercial license from the RECIPIENT and the RECIPIENT has no obligation to grant a commercial license to its ownership interest in the MATERIAL. Nothing in this paragraph, however, shall prevent the PROVIDER from granting commercial licenses under the PROVIDER's intellectual property rights claiming such MATERIAL, or methods of their manufacture or their use.
e) The RECIPIENT and/or the RECIPIENT SCIENTIST shall have the right, without restriction, to distribute MODIFICATIONS for COMMERCIAL PURPOSES. It is recognized by the RECIPIENT that such COMMERCIAL PURPOSES may NOT require a commercial license from the PROVIDER and the PROVIDER has no obligation to grant a commercial license to its ownership interest in the MATERIAL incorporated in the MODIFICATIONS. Nothing in this paragraph, however, shall prevent the RECIPIENT from granting commercial licenses under the RECIPIENT's intellectual property rights claiming such MODIFICATIONS, or methods of their manufacture or their use.

6. The RECIPIENT acknowledges that the MATERIAL is or may be the subject of a patent application. Except as provided in this Agreement, no express or implied licenses or other rights are provided to the RECIPIENT under any patents, patent applications, trade secrets or other proprietary rights of the PROVIDER, including any altered forms of the MATERIAL made by the PROVIDER. In particular, no express or implied licenses or other rights are provided to use the MATERIAL, MODIFICATIONS, or any related patents of the PROVIDER for COMMERCIAL PURPOSES.

7. If the RECIPIENT desires to use or license the MATERIAL for COMMERCIAL PURPOSES, the RECIPIENT agrees, in advance of such use, to negotiate in good faith with the PROVIDER to establish the terms of a commercial license. It is understood by the RECIPIENT that the PROVIDER shall have no obligation to grant such a license to the RECIPIENT, and may grant exclusive or non-exclusive commercial licenses to others, or sell or assign all or part of the rights in the MATERIAL to any third party(ies), subject to any pre-existing rights held by others and obligations to the Federal Government.

8. If the PROVIDER desires to use or license the MODIFICATIONS for COMMERCIAL PURPOSES, the PROVIDER agrees, in advance of such use, to negotiate in good faith with the RECIPIENT to establish the terms of a commercial license. It is understood by the PROVIDER that the RECIPIENT shall have no obligation to grant such a license to the PROVIDER, and may grant exclusive or non-exclusive commercial licenses to others, or sell or assign all or part of the rights in the MODIFICATIONS to any third party(ies), subject to any pre-existing rights held by others and obligations to theGovernment.

9. The PROVIDER is free to file patent application(s) claiming inventions made by the PROVIDER through the use of the MODIFICATIONS but agrees to notify the RECIPIENT upon filing a patent application claiming MATERIAL or method(s) of manufacture or use(s) of the MATERIAL.

10. The RECIPIENT is free to file patent application(s) claiming inventions made by the RECIPIENT through the use of the MATERIAL but agrees to notify the PROVIDER upon filing a patent application claiming MODIFICATIONS or method(s) of manufacture or use(s) of the MATERIAL.

11. Any MATERIAL delivered pursuant to this Agreement is understood to be experimental in nature and may have hazardous properties. The PROVIDER MAKES NO REPRESENTATIONS AND EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESSED OR IMPLIED. THERE ARE NO EXPRESS OR IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR THAT THE USE OF THE MATERIAL WILL NOT INFRINGE ANY PATENT, COPYRIGHT, TRADEMARK, OR OTHER PROPRIETARY RIGHTS.

12. Except to the extent prohibited by law, the RECIPIENT assumes all liability for damages which may arise from its use, storage or disposal of the MATERIAL. The PROVIDER will not be liable to the RECIPIENT for any loss, claim or demand made by the RECIPIENT, or made against the RECIPIENT by any other party, due to or arising from the use of the MATERIAL by the RECIPIENT, except to the extent permitted by law when caused by the gross negligence or willful misconduct of the PROVIDER.

13. This agreement shall not be interpreted to prevent or delay publication of research findings resulting from the use of the MATERIAL or the MODIFICATIONS. The PROVIDER SCIENTIST agrees to provide appropriate acknowledgment of the source of the MODIFICATIONS in all publications. The RECIPIENT SCIENTIST agrees to provide appropriate acknowledgment of the source of the MATERIAL in all publications.

14. The PROVIDER agrees to use the MODIFICATIONS in compliance with all applicable statutes and regulations, including Public Health Service and National Institutes of Health regulations and guidelines such as, for example, those relating to research involving the use of animals or recombinant DNA. The RECIPIENT agrees to use the MATERIAL in compliance with all applicable statutes and regulations, including Public Health Service and National Institutes of Health regulations and guidelines such as, for example, those relating to research involving the use of animals or recombinant DNA.

i) if termination should occur under 15(a), the RECIPIENT shall be bound to the PROVIDER by the least restrictive terms applicable to the MATERIAL obtained from the then-available resources; and
ii) if termination should occur under 15(b) or (d) above, the RECIPIENT will discontinue its use of the MATERIAL and will, upon direction of the PROVIDER, return or destroy any remaining MATERIAL. The RECIPIENT, at its discretion, will also either destroy the MODIFICATIONS or remain bound by the terms of this agreement as they apply to MODIFICATIONS; and
iii) In the event the PROVIDER terminates this Agreement under 15( c) other than for breach of this Agreement or for cause such as an imminent health risk or patent infringement, the PROVIDER will defer the effective date of termination for a period of up to one year, upon request from the RECIPIENT, to permit completion of research in progress. Upon the effective date of termination, or if requested, the deferred effective date of termination, RECIPIENT will discontinue its use of the MATERIAL and will, upon direction of the PROVIDER, return or destroy any remaining MATERIAL. The RECIPIENT, at its discretion, will also either destroy the MODIFICATIONS or remain bound by the terms of this agreement as they apply to MODIFICATIONS.

16.Paragraphs 6, 11 and 12 shall survive termination.

17.The MATERIAL is provided at no cost, or with an optional transmittal fee solely to reimburse the PROVIDER for its preparation and distribution costs. If a fee is requested by the PROVIDER, the amount will be indicated in an implementing letter. Main Text Ends Here.

RECIPIENT: Kangma-Healthcode (Shanghai) Biotech Co. Ltd.
RECIPIENT SCIENTIST: Rongrong Zhan
RECIPIENT ADDRESS: Building 15, Lane 118 Furonghua Road, Shanghai 201321, CHINA
RECIPIENT TEL: 021-58086922
RECIPIENT EMAIL: customer@healthcodon.com

Protocol Specification

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Endotoxin Remover- OurProteinFactory

Endotoxin Remover

Product code

PROTN_5FZER150

224.87 ￥ 58.53

Size

60 mL

150 mL

300 mL

Quantity

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Document

Endotoxin Remover

Protein Factory Endotoxin Removal Products.

Endotoxin Removal is stable, convenient and efficient.

SOURCE OF ENDOTOXIN

Endotoxin is a kind of lipopolysaccharide derived from the outer membrane of Gram-negative bacteria and is an important contaminant of biological products.

内毒素是一种来源于革兰氏阴性菌外膜的脂多糖，是生物制品的重要污染物。

A small amount of endotoxin can cause fever, and in severe cases, it may cause disseminated intravascular coagulation, shock, fever and inflammatory reaction.

少量内毒素便可引起机体发热，严重时可能引起播散性血管内凝血、休克、发热及炎症反应。

The drug regulatory authorities of various countries also have strict requirements on the endotoxin content of biological products. Therefore, it is very necessary to remove the endotoxin in the sample to ensure its safety.

各国药监部门对生物制品内毒素的含量也都有着严格的要求。因此，去除样品中的内毒素保证其安全性是非常有必要的。

The most common Escherichia coli

最常见的大肠杆菌

Shigella that can cause bacillary dysentery

可引起细菌性痢疾的志贺菌属

Typhoid bacillus that can cause fever

可致机体发热的伤寒杆菌

TECHNICAL

BACKGROUND

PEOTEINN Endotoxin Remover is an authoritative and classical phase separation method for the efficient removal of high concentrations of endotoxins and other lipophilic substances from samples, up to 99% efficiency without affecting the activity of the active ingredient. The product can be used for a variety of subsequent animal and cell biology operations.

PEOTEINN 去内毒素产品采用的是权威而经典的相分离法，充分有效地清除样品中高浓度内毒素和其它亲脂性物质，高达99％以上效率且不影响有效成份的活性。产物可用于各种后续动物和细胞生物学操作。

READY-TO-USE

即到即用

EASY OPERATION

操作方便

STABLE PERFORMANCE

性能稳定

EFFICIENT REMOVAL

高效清除

PROTEINN offers 60mL~300mL Endotoxin Remover to meet your different needs.

PROTEINN提供60mL~300mL规格去内毒素试剂，满足您的不同使用需求

ENDOTOXIN REMOVER

STORAGE METHOD

去内毒素试剂保存方式

STORE IN 2~8℃ MEDICAL REFRIGERATOR

在2~8℃医用冷藏箱储存

ENDOTOXIN REMOVER OPERATION PROCESS

去内毒素操作流程

PROTOTOL:

1. Prepare samples.

2. Pipette 1mL sample into a 1.5mL centrifuge tube.

3. Add 50 μL solution NU.

4. Add 200 μL of pre-cooled ER solution (Endotoxin Remove).

5. 10 seconds of vortex oscillation.

6. Leave it in an ice bath for 5 minutes, then let it stand in a 37℃ water bath for 5 minutes, inverting and mixing twice during this period, the solution becomes turbid.

7. Put it in a centrifuge and centrifuge at room temperature for 10 minutes at a speed of 12000rpm.

8. After centrifugation, the solution is divided into two phases. Carefully transfer the supernatant to a new 1.5 mL centrifuge tube, and discard the lower oily phase.

9. Repeat steps 3~8, ER treatment 3 times, the endotoxin in the sample can be reduced to below 0.1EU/μL.

10. Save it for later use or continue with subsequent standard experimental operations.

1、准备样品；

2、移取1mL 样品置于1.5mL离心管；

3、加入50 μL溶液NU；

4、加入200 μL 预冷的ER溶液(Endotoxin Remove)；

5、涡旋震荡10秒；

6、冰浴静置5分钟，再37℃水浴静置5分钟，期间颠倒混匀2次，溶液变浑浊；

7、放入离心机，室温离心10分钟，速度为12000rpm；

8、离心结束，溶液分为两相，小心移取上清液至新1.5 mL离心管，弃下层油状相；

9、重复步骤3~8，ER处理共3次，样品中内毒素可降至0.1EU/μL以下；

10、保存备用或继续进行后续标准实验操作。

PRECAUTIONS:

a. Wear gloves when operating;

b. The operating utensils should not contain endotoxin;

c. When using, avoid contamination of mother liquor;

d. ER (Endotoxin Remove) storage temperature is 2~8℃;

e. For operations with different sample volumes, it is recommended to adjust the amount of reagents accordingly;

f. Serum samples use the same steps, but must be performed aseptically;

g. The degree of endotoxin removal depends on the endotoxin content in the sample and the nature of the sample (bacterial source, fusion protein characteristics), and can be completely removed through multiple treatments. Due to the nature of the plasmid DNA, part of the plasmid DNA will be lost during the removal process, but the endotoxin will be removed to the maximum;

h. The endotoxin content of the product after treatment with this product can be less than 0.1EU/μL;

i. The company provides a series of protein products and endotoxin removal reagent products.

a.操作时，须戴手套；

b.操作器皿应不含内毒素；

c.使用时，避免污染母液；

d.ER(Endotoxin Remove)储存温度为2~8℃；

e.不同样品容量的操作，建议相应调整试剂用量；

f.血清样品采用相同操作步骤，但须无菌操作；

g.去内毒素程度取决于样品中内毒素含量和样品性质（细菌来源、融合蛋白特性），可以通过多次处理，达到彻底清除的效果。由于质粒DNA本身的性质，清除过程会导致部分质粒DNA丢失，但内毒素会最大限度清除；

h.经过本产品处理后的产物内毒素含量可低于0.1EU/μL；

i.本公司提供系列蛋白质产品及去内毒素试剂产品。

CHARACTERISTIC

产品特性

Product Name：	Product Number:	Size:
Endotoxin Remover	PROTN_5FZER60	60 mL / 150 mL / 300 mL
Storage Temperature:	Precautions:	Package Contents:
2~8℃	Operating utensils should be endotoxin-free	ER+NU
Effectiveness:	Shelf Life:	Adapting Methods:
< 0.1 EU/μL	12 months	Phase separation

FOOT

More ways to contact,Building #12-15, Furonghua Road, Pudong District, Shanghai, China Zip: 200120， please call +1-800-955-3390or+86-400-770-5500Monday to Sunday 0:00-24:00